XL BCL6 BA
The XL BCL6 BA probe is designed as a break apart probe. Its green labeled part hybridizes proximal to the BCL6 gene at 3q27, the orange labeled probe hybridizes to the region distal of BCL6.
This probe is intended for methanol/acetic-acid fixed cells and tissue sections.
Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBL) represent the two most common entities of non-Hodgkin\'s lymphoma (NHL) worldwide with up to 22% and 31% of tumors, respectively. FLs have been classically associated with the translocation t(14;18)(q32;q21) in 70% to 95% of reported tumors, whereas translocations involving the BCL6 proto-oncogene locus in chromosomal band 3q27 are encountered in 6% to 14%. In DLBLs a BCL6 translocation can be found in up to 40% of cases, while BCL2 translocations occur in 20% to 30%.
The relative wide separation of the probe binding sites allows for the detection of translocations in the MBR (major breakpoint cluster region) as well as in the ABR (alternative breakpoint cluster region).
Cena za kus: pro registrované
This probe is intended for methanol/acetic-acid fixed cells and tissue sections.
Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBL) represent the two most common entities of non-Hodgkin\'s lymphoma (NHL) worldwide with up to 22% and 31% of tumors, respectively. FLs have been classically associated with the translocation t(14;18)(q32;q21) in 70% to 95% of reported tumors, whereas translocations involving the BCL6 proto-oncogene locus in chromosomal band 3q27 are encountered in 6% to 14%. In DLBLs a BCL6 translocation can be found in up to 40% of cases, while BCL2 translocations occur in 20% to 30%.
The relative wide separation of the probe binding sites allows for the detection of translocations in the MBR (major breakpoint cluster region) as well as in the ABR (alternative breakpoint cluster region).
Cena za kus: pro registrované
