XL NUP98
The XL NUP98 probe is designed as a break apart probe. Its orange labeled part hybridizes proximal to the NUP98 gene at 11p15, the green labeled probe hybridizes to the distal region of NUP98.
Several recurrent balanced translocations and inversions, and their variants, are
recognized in the WHO category AML with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features when 20% or more blood or marrow blasts are present.
Translocations involving nucleoporin 98kD (NUP98) on chromosome 11p15 occur at relatively low frequency in acute myeloid leukemia (AML), but can be missed with routine karyotyping. NUP98 is known to be fused to at least 28 different partner genes
in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic
myeloid leukemia in blast crisis, myelodysplastic syndrome, acute lymphoblastic
leukemia, and bilineage/biphenotypic leukemia.
Cena za kus: pro registrované
Several recurrent balanced translocations and inversions, and their variants, are
recognized in the WHO category AML with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features when 20% or more blood or marrow blasts are present.
Translocations involving nucleoporin 98kD (NUP98) on chromosome 11p15 occur at relatively low frequency in acute myeloid leukemia (AML), but can be missed with routine karyotyping. NUP98 is known to be fused to at least 28 different partner genes
in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic
myeloid leukemia in blast crisis, myelodysplastic syndrome, acute lymphoblastic
leukemia, and bilineage/biphenotypic leukemia.
Cena za kus: pro registrované
