XL TET2
The XL TET2 locus-specific probe detects deletions in 4q24. This probe is labeled in orange and extends from marker RH43141 proximal to RH69608 distal of the TET2 gene. A green labeled probe hybridizes to 4q12, functioning as a reference probe.
The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid
cells. According to WHO classification (2008) cytogenetic aberrations are observed in about 50 % of MDS cases. The most
common aberrations are 5q-, 7/7q-, trisomy 8, del(20q), and inv(3) or t(3;3).
A minimally deleted region on chromosome 4q24 is described in subgroups of patients with myelodysplastic syndromes
and acute myeloid leukemia (AML). The region encompasses the TET2 gene. The frequency of TET2 mutations in unselected
patients was 19 % (15 of 81 patients) with myelodysplastic syndromes, 12 % (24 of 198 patients) with myeloproliferative
disorders, 24 % (5 of 21 patients) with secondary AML, and 22 % (2 of 9 patients) with chronic myelomonocytic leukemia.
Cena za kus: pro registrované
The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid
cells. According to WHO classification (2008) cytogenetic aberrations are observed in about 50 % of MDS cases. The most
common aberrations are 5q-, 7/7q-, trisomy 8, del(20q), and inv(3) or t(3;3).
A minimally deleted region on chromosome 4q24 is described in subgroups of patients with myelodysplastic syndromes
and acute myeloid leukemia (AML). The region encompasses the TET2 gene. The frequency of TET2 mutations in unselected
patients was 19 % (15 of 81 patients) with myelodysplastic syndromes, 12 % (24 of 198 patients) with myeloproliferative
disorders, 24 % (5 of 21 patients) with secondary AML, and 22 % (2 of 9 patients) with chronic myelomonocytic leukemia.
Cena za kus: pro registrované
