XL TP53/17cen
The XL TP53/17cen probe detects deletions which occur in 17p13 and which involve the TP53 locus. The specific probe is labeled in orange while a green labeled probe which hybridizes to the centromere of chromosome 17 functions as a reference probe.
TP53 is described as \'the guardian of the genome\' because of its role in conserving stability by preventing genome mutation. Therefore TP53 is classified as a tumor suppressor gene. It has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. If the TP53 gene is damaged tumor suppression is severely reduced.
The TP53 gene is located on the short arm of chromosome 17 (17p13.1). More than 50 % of human tumors contain either a mutation or deletion of the TP53 gene.
Cena za kus: pro registrované
TP53 is described as \'the guardian of the genome\' because of its role in conserving stability by preventing genome mutation. Therefore TP53 is classified as a tumor suppressor gene. It has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. If the TP53 gene is damaged tumor suppression is severely reduced.
The TP53 gene is located on the short arm of chromosome 17 (17p13.1). More than 50 % of human tumors contain either a mutation or deletion of the TP53 gene.
Cena za kus: pro registrované
