XL ROS1-GOPC BA
The XL ROS1-GOPC BA probe is designed as a break apart probe. Its green labeled part hybridizes proximal to the ROS1 gene at 6q22 and the orange labeled probe hybridizes to the distal region of ROS1. This probe is also suited to analyze the ROS1-GOPC (formerly called FIG-ROS) fusion, caused by an interstitial deletion of 240 kb in size.
This probe is intended for methanol/acetic-acid fixed cells and tissue sections.
Translocations involving the ROS1 receptor tyrosine kinase gene have recently been described in a subset of non-small-cell lung cancers (NSCLCs). Chromosomal rearrangements involving the ROS1 gene were originally described in glioblastomas, where ROS1 is fused to the GOPC gene by an interstitial deletion.
Fusions of ROS1 with other genes lead to constitutive kinase activity and are associated with sensitivity in vitro to tyrosine kinase inhibitors such as Crizotinib.
Cena za kus: pro registrované
This probe is intended for methanol/acetic-acid fixed cells and tissue sections.
Translocations involving the ROS1 receptor tyrosine kinase gene have recently been described in a subset of non-small-cell lung cancers (NSCLCs). Chromosomal rearrangements involving the ROS1 gene were originally described in glioblastomas, where ROS1 is fused to the GOPC gene by an interstitial deletion.
Fusions of ROS1 with other genes lead to constitutive kinase activity and are associated with sensitivity in vitro to tyrosine kinase inhibitors such as Crizotinib.
Cena za kus: pro registrované