XL 5p15/9q22/15q22 Hyperdiploidy
The XL 5p15/9q22/15q22 Hyperdiploidy probe is designed as a triple color assay and allows enumeration of chromosomes 5, 9 and 15. A green labeled probe hybridizes to a region at 5p15, a blue one to the 9q22 region, and an orange one to the 15q22 region.
In multiple myeloma (MM) pathogenesis hyperdiploidy and non-hyperdiploidy are recognized as two major cytogenetic pathways. The hyperdiploid group is characterized by gains of the odd chromosomes 3, 5, 7, 9, 11, 15, 19, and 21. Hyperdiploidy has been internationally defined and requires trisomy for at least 2 of the 3 chromosomes 5, 9, and 15.
Patients with hyperdiploid multiple myeloma, which can be observed in 50-60% of patients, tend to have a better prognosis than those with a non-hyperdiploid subtype.
Cena za kus: pro registrované
In multiple myeloma (MM) pathogenesis hyperdiploidy and non-hyperdiploidy are recognized as two major cytogenetic pathways. The hyperdiploid group is characterized by gains of the odd chromosomes 3, 5, 7, 9, 11, 15, 19, and 21. Hyperdiploidy has been internationally defined and requires trisomy for at least 2 of the 3 chromosomes 5, 9, and 15.
Patients with hyperdiploid multiple myeloma, which can be observed in 50-60% of patients, tend to have a better prognosis than those with a non-hyperdiploid subtype.
Cena za kus: pro registrované
