XL TCRA/D
The XL TCRA/D is designed as break apart probe. An orange labeled probe covers the region proximal to TCRA/D at 14q11, and a green labeled probe covers the region distal to the TCRA/D gene.
Chromosomal aberrations with breakpoints in T-cell receptor (TCR) gene loci are recurrent in several T-cell malignancies. The chromosomal alterations juxtapose oncogenes next to TCR regulatory sequences leading to deregulated expression of those oncogenes.
T-cell prolymphocytic leukemia (T-PLL) harbors frequent alterations of the TCRA/D locus, usually caused by an inv(14)(q11q32). By molecular cytogenetics studies, the incidence of
TCRA/D rearrangements is about 24% of all T-ALL cases.
Cena za kus: pro registrované
Chromosomal aberrations with breakpoints in T-cell receptor (TCR) gene loci are recurrent in several T-cell malignancies. The chromosomal alterations juxtapose oncogenes next to TCR regulatory sequences leading to deregulated expression of those oncogenes.
T-cell prolymphocytic leukemia (T-PLL) harbors frequent alterations of the TCRA/D locus, usually caused by an inv(14)(q11q32). By molecular cytogenetics studies, the incidence of
TCRA/D rearrangements is about 24% of all T-ALL cases.
Cena za kus: pro registrované
