XL MYC BA Triple color
The XL MYC BA Triple-color probe is designed as a triple-color break apart probe. Its orange labeled part hybridizes proximal to the MYC gene at 8q24, the green labeled probe hybridizes to the distal region of MYC, and a blue (aqua) labeled probe covers MYC and adjacent regions.
This probe is intended for methanol/acetic-acid fixed cells and tissue sections.
Translocations involving MYC are observed in diffuse large-B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and other lymphomas. In Burkitt Lymphoma the MYC gene, located at 8q24, is activated by a translocation next to an immunoglobulin constant gene. Most frequently MYC is positioned near the immunoglobulin heavy-chain (IGH) constant region on chromosome 14q32. However in some tumors, MYC can also be positioned near the light-chain region on chromosome 2p11 (IGK) or 22q11 (IGL). In addtion other translocation partners have been identified (e.g. BCL11A, PAX5, ZCCHC7).
The XL MYC BA Triple-color probe is designed as a break apart probe with three probes juxtaposed and differently labeled. In cases with 8q24 rearrangment the co-localization patterns of orange-blue versus green-blue allows to distinguish different breakpoints in MYC translocations which can be an aid in diagnosis.
Cena za kus: pro registrované
This probe is intended for methanol/acetic-acid fixed cells and tissue sections.
Translocations involving MYC are observed in diffuse large-B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and other lymphomas. In Burkitt Lymphoma the MYC gene, located at 8q24, is activated by a translocation next to an immunoglobulin constant gene. Most frequently MYC is positioned near the immunoglobulin heavy-chain (IGH) constant region on chromosome 14q32. However in some tumors, MYC can also be positioned near the light-chain region on chromosome 2p11 (IGK) or 22q11 (IGL). In addtion other translocation partners have been identified (e.g. BCL11A, PAX5, ZCCHC7).
The XL MYC BA Triple-color probe is designed as a break apart probe with three probes juxtaposed and differently labeled. In cases with 8q24 rearrangment the co-localization patterns of orange-blue versus green-blue allows to distinguish different breakpoints in MYC translocations which can be an aid in diagnosis.
Cena za kus: pro registrované
